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In microbiology, minimum inhibitory concentration (MIC) is the lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation. Minimum inhibitory concentrations are important in diagnostic laboratories to confirm resistance of microorganisms to an antimicrobial agent and also to monitor the activity of new antimicrobial agents. A MIC is generally regarded as the most basic laboratory measurement of the activity of an antimicrobial agent against an organism.〔Turnidge JD, Ferraro MJ, Jorgensen JH (2003) Susceptibility Test Methods: General Considerations. In PR Murray, EJ Baron, JH Jorgensen, MA Pfaller, RH Yolken. Manual of Clinical Microbiology. 8th Ed. Washington. American Society of Clinical Microbiology. p 1103 ISBN 1-55581-255-4〕 ==Determination== MIC of an antibiotic is determined by using the following procedure:〔 # Preparation of antibiotic stock solution # Preparation of antibiotic dilution range # Preparation of agar dilution plates # Preparation of inoculum # Inoculation # Incubation # Reading and interpreting results MICs can be determined by agar dilution or broth microdilution, usually following the guidelines of a reference body such as the CLSI, (BSAC ) or (EUCAST ). There are several commercial methods available, including the well established Etest strips and the recently launched Oxoid MIC Evaluator method. The Etest system comprises a predefined and continuous concentration gradient of different antimicrobial agents, which when applied to inoculated agar plates and incubated, create ellipses of microbial inhibition.() The MIC is determined where the ellipse of inhibition intersects the strip, and is easily read off the MIC reading scale on the strip.() 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「minimum inhibitory concentration」の詳細全文を読む スポンサード リンク
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